Description

Basics on stem cells and cell engineering applications in different clinical areas, involved in cardiovascular, immunological and endocrine systems.
The lectures will be subdivided in 2 mains parts: after the presentation of the main properties of stem cells, a presentation and description of each main stem cell including their functional activities will be performed. The European regulatory context of clinical cell engineering will be presented. In a second part, different engineering applications will be presented including basic science, pre-clinical models and clinical transfer experiences. Special attention will be paid to the manufacturing of cells in a clinical setting to comply with Advanced Therapy Medicinal Product status,
Each teaching course of the second part will be composed of 1 h of lecture and 1 h of tutorial.
Tutorials will consist in the critical analysis of recent publications related to the topics of the lectures. Students will present the publication or part of a publication they had to study.

Compétences visées

Knowledge in different areas of basic and clinical research in cell engineering.

Modalités d'organisation et de suivi

• 20 h teaching and 11 h tutorial sessions, encouraging multidisciplinary and cultural exchanges through the constitution of work groups.
• Teaching slides, including those from tutorials, and when possible recordings will be provided.
• Pedagogical games and during tutorials one short teaching (under supervision) by student groups will performed.
• Evaluation: Written exam: 60 min with different questions on different topics covered in this teaching. Questions on the lessons but also figures from publications to explain or comment.

Bibliographie

• MOOC “Ingénierie cellulaire et tissulaire” from UL (plateform Fun, opening in May 2018)
• General Immunology books
• Cell biology books