Description

Lectures will focus on major metabolic diseases including dyslipidemia and diabetes. For each type of pathology, the definition and symptoms will be provided and the underlying molecular and cellular mechanisms will be developed. Different experimental models of these metabolic diseases will be presented and their relevance to the human disease discussed. The mechanism of action of the present pharmacological treatments and their major side effects will be developed. Moreover, novel targets for drug development will be presented.
Tutorials will focus on novel targets for the treatment of these metabolic diseases. Data from published articles using experimental models of metabolic diseases will be used to prepare a poster, which will be presented to all students.
 

Compétences visées

Knowledge of pathophysiological mechanisms involved in the development of major metabolic diseases, relevance and limitation of actual and future treatment targets and of experimental models of metabolic diseases.
 

Modalités d'organisation et de suivi

• 8 h teaching and 24 h tutorial sessions, encouraging multidisciplinary and cultural exchanges.
• Teaching slides, including those from tutorials, and when possible recordings will be provided.
• Evaluation: First session: Written exam: 90 min based on the analysis of data of an experimental study on a metabolic disease (2/3%) + oral presentation and discussion of a poster (1/3%). Second session: oral examination.

Bibliographie

• Medscape & Education (Medscape@mail.medscape.org)

Contacts

Responsable(s) de l'enseignement

• Jean-Marc Lessinger
• Romeo Ricci