Biological responses: from targets to treatments

Biological responses: from targets to treatments
Master Biologie-santéParcours International Master of Biomedicine

Credits3 crédits

Description

Lectures will present major mechanisms involved in the control of vascular and cardiac homeostasis under physiological conditions and their alteration during physiological ageing. Both molecular and cellular mechanisms involved in the local and neuronal regulation of the cardiovascular structure and function will be described as well as the interaction of blood cells and blood-derived factors on the cardiovascular system. The different elements of these regulatory systems and their alteration during ageing will be developed. For each regulatory system, the actual and potential targets for therapeutic intervention will be discussed. The lectures are based predominantly on published articles. Tutorials will illustrate ageing-related cardiovascular dysfunctions in experimental animals and humans based on published articles.

Compétences visées

Knowledge of the major systems and their different elements contributing to the regulation of cardiovascular homeostasis and their alteration during physiological ageing. For each regulatory system, the student will be able to identify the key targets enabling the modulation of the cardiovascular system and discuss its pertinence.

Modalités d'organisation et de suivi

  • 20 h teaching and 8 h tutorial sessions, encouraging multidisciplinary and cultural exchanges.
  • Teaching slides, including those from tutorials, and when possible recordings will be provided.
  • Evaluation: First session: Written exam: 90 min based on a biological system involving different cell types and mediators, identification of major targets to modify the biological response. Second session: oral examination

Bibliographie

  • « Pharmacologie. des cibles vers l'indication thérapeutique » de Yves Landry, Jean Pierre Gies, éditeur collection Sciences su, Edition DUNOD.
  • Goodman and Gilman’s. The Pharmacological Basis of Therapeutics. 13th Edition
  • Web sites: http://www.cellsignallingbiology.org/csb/mikeb.htm; htttp://www.ncbi.nlm.nih.gov.pubmed
  • IUPHAR: http://www.guidetopharmacology.org

Contacts

Responsable(s) de l'enseignement

Université numérique en santé et sport
Les Hôpitaux Universitaires de Strasbourg
Agence régionale de santé
Centre d'étude et de conservation des oeufs et du sperme
Institut de cancérologie Strasbourg
Institut hospitalo-universitaire
Établissement français du sang
Association amicale des étudiants en médecine de Strasbourg
Mouvement des étudiant.e.s alsacien.ne.s futur.e.s orthophonistes
Association strasbourgeoise des étudiants en Orthoptie
L'association Tutorat Santé de Strasbourg
Amicale des Étudiants Sages-Femmes d'Alsace
Réseau des Étudiants Soignants des Hôpitaux Universitaires de Strasbourg
Institut national de la santé et de la recherche médicale
Centre national de la recherche scientifique
Fédération de médecine translationnelle de Strasbourg
Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie
Institut de génétique et de biologie moléculaire et cellulaire
Centre de recherche en biomédecine de Strasbourg - CRBS
Conférence des doyens des facultés de médecine
Faculté de sciences de la vie
Faculté de chirurgie dentaire
Faculté de pharmacie